科研团队

姓名：张壮壮

职称： 副研究员
电话： 15141709575
电子邮件： zhangzhzh36@mail.sysu.edu.cn
通讯地址： 珠海市香洲区梅华东路52号中山大学附属第五医院分子影像中心

学历和工作经历

中山大学附属第五医院副研究员。2008年于安徽医科大学获医学学士学位。2011年于上海交通大学医学院获理学硕士学位。2015年于上海交通大学医学院获理学博士学位。2016-2018年于美国普渡大学（Purdue University）从事博士后研究（博士后助理研究员）。2018-2020年于肯塔基大学（University of Kentucky）继续从事博士后研究（博士后副研究员）。2020.9-2023-3任职美国肯塔基大学Research Scientist。共发表SCI论文18篇，其中一作和共同一作SCI论文8篇，一区4篇；二区3篇；三区1篇。2021年获肯塔基大学Research Fellowship， 2022年入选上海市海外高层次人才引进计划。

研究方向

前列腺癌和胰腺癌发病机制及耐药机制的研究、肿瘤免疫治疗

代表性成果

近期代表性论文

1. Zhuangzhuang Zhang^#,..., Xiaoqi Liu*. Inhibition of the Wnt/β-Catenin Pathway Overcomes Resistance to Enzalutamide in Castration-Resistant Prostate Cancer, Cancer Research, 2018, 78(12): 3147-3162.

2. Zhuangzhuang Zhang^#, Lijun Cheng^#, Jie Li^#, ..., Xiaoqi Liu*. Targeting Plk1 sensitizes pancreatic cancer to immune checkpoint therapy, Cancer Research, 2022, 82(19): 3532-3548.

3. Zhuangzhuang Zhang^#, Lijun Cheng^#, ..., Xiaoqi Liu*. Co‐Targeting Plk1 and DNMT3a in Advanced Prostate Cancer, Advanced Science, 2022, 9(20): 2202572(1)-2202572(16).

4. Yunfeng Bai^#, Zhuangzhuang Zhang^#, ..., Xiaoqi Liu*.Inhibition of enhancer of zeste homolog 2 (EZH2) overcomes enzalutamide resistance in castration-resistant prostate cancer, Journal of Biological Chemistry, 2019, 294(25): 9911-9923

5. Elia Farah^#, Zhuangzhuang Zhang^#, ..., Xiaoqi Liu*. Targeting DNMTs to Overcome Enzalutamide Resistance in Prostate Cancer, Molecular Cancer Therapeutics, 2021, 21(1): 193-205.

6. Zhuangzhuang Zhang^#, Jian Huang^#, Yuping Wang^#,..., Ze-Guang Han*. NOXIN as a cofactor of DNA polymerase-primase complex could promote hepatocellular carcinoma, International Journal Of Cancer, 2015, 4(137): 765-775.

7. Jiaoxiang Wu^#, Kunyan He^#, Zhuangzhuang Zhang^#, ..., Zeguang Han*. LZP is required for hepatic triacylglycerol transportation through maintaining apolipoprotein B stability, PLOS Genetics, 2021, 17(2): e1009357-e1009357.

获奖及荣誉

2011年：Talent New Ph.D Student Scholarship of SJTU

2012年：Excellent Ph.D. Candidate Scholarship of SJTU

2013年：Excellent Ph.D. Candidate Scholarship of SJTU

2014年：The foundation for fostering talent Ph.D. candidates of SJTU

2020年：Travel award, Markey Cancer Center of University of Kentucky

2021年：Research Fellowship of University of Kentucky

2022年：Review editor within journal Frontiers in Oncology

2022年：Sponsored by the Talent Program of Shanghai Municipality in 2022 (入选2022上海市海外高层次人才引进计划)