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姓名:严彦

职称: 副研究员
电话: 0756-2526140,13823000497
电子邮件: yanyan35@mail.sysu.edu.cn
通讯地址: 广东省珠海市香洲区梅华东路52号,中山大学附属第五医院

学历和工作经历

2017/08-至今,中山大学,附属第五医院,副研究员

2016/07-2017/07,新加坡国立大学,资深博士后

2012/02-2016/06,新加坡国立大学,博士后

2006/01-2011/11,南洋理工大学(新加坡),博士

研究方向

1. 感染与固有免疫

2. 微生物菌群与肿瘤

3. Hippo信号通路

承担科研项目情况

在研科研项目:

1. 国家自然科学基金,面上项目,82170029,肺泡II型上皮细胞YAP/TGFβ2/CTGF通路参与哮喘终末气道纤维化的作用机制研究 2022/01-2025/12,主持

2. 国家自然科学基金,面上项目,81870019 ,CD151在鼻病毒诱导型哮喘气道重塑中的作用及分子机制研究,2019/01-2022/12,主持

已完成科研项目:

1. 广东省自然科学基金,自由申请项目,2018A030313554 ,RV16鼻病毒感染气道上皮细胞激活成纤维细胞的分子机制及其在慢性气道炎症疾病中的病理作用研究,2018/05-2021/04,主持

2. 广州市产学研协同创新重大专项民生科技研究,TSLP-Hippo/YAP通路介导成纤维细胞转分化在重症哮喘气道重塑中的作用,2017/01-2019/12,参与

3. 中山大学“百人计划”科研启动项目,免疫学,2017/09-2020/08,主持

代表性成果

1. Yuan-Yang Tan#,Hui-Qin Zhou#, Yu-Jing Lin#, Liu-Tong Yi#, Zhuang-GuiChen, Qing-Dong Cao, Yan-Rong Guo, Zhao-Ni Wang, Shou-Deng Chen, Yang Li,De-Yun Wang, Yong-Kang Qiao*, Yan Yan*.FGF2 is overexpressed in asthma and promotes airway inflammation throughFGFR/MAPK/NF-κB pathway in airway epithelial cells. Mil Med Res, 2022, 9:7

2. Guihua Zhong#,Wei Wei#, Wei Liao#, Rong Wang, Yingpeng Peng, YulingZhou, Xiaotao Huang, Shiping Xian, Shunli Peng, Zhaoyuan Zhang, Shaoyan Feng,Ye Liu, Haiyu Hong, Yunfei Xia, Yan Yan*,Qiaodan Liu*, Zhigang Liu*. Tumor microbiome in nasopharyngeal carcinoma andits association with prognosis. Front Oncol, 2022 May 23;12:859721.

3. Haiyu Hong#,Kai Sen Tan#, Yan Yan#,Fenghong Chen#, Hsiao Hui Ong, Yukei Oo, Jing Liu, Yew Kwong Ong,Mark Thong, Richard Sugrue, Vincent T Chow*, De-Yun Wang*. Induction of IL-25Expression in Human Nasal Polyp Epithelium by Influenza Virus Infection isAbated by Interferon-Alpha Pretreatment. J Inflamm Res, 2021.14:2769-2780.

4.Yuanyang Tan#, Yongkang Qiao#, Zhuanggui Chen, Jing Liu, Yanrong Guo, Thai Tran, Kai Sen Tan, De-Yun Wang*, Yan Yan*. FGF2, an immunomodulatory factor in asthma and chronic obstructive pulmonary disease (COPD). Front Cell Dev Biol, 2020,8:223.

5. Zhaoni Wang#, Ruonan Su#, Biyun Yang, Kexin Yang, Lifen Yang, Yan Yan*, Zhuanggui Chen*.Potential role of cellular senescence in asthma. Front Cell Dev Biol, 2020,8:59.

6. Yan-Rong Guo #, Qing-Dong Cao #, Zhong-Si Hong #, Yuan-Yang Tan, Shou-Deng Chen, Hong-Jun Jin, Kai Sen Tan, De-Yun Wang*, Yan Yan*. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res, 2020 Mar 13;7(1):11.

7. KaiSen Tan#, Anand Kumar Andiappan#, Bernett Lee#, Yan Yan#, Jing liu#,See Aik Tang, Josephine Lum, Yew Kwang Ong, Kim Thye Thong, Hui Fang Lim, HyungWon Choi, Olaf Rotzschke, Vincent T Chow*, De Yun Wang*. RNA sequencing of H3N2influenza virus-infected human nasal epithelial cells from multiple subjectsreveals molecular pathways associated with tissue injury and complications.Cells, 2019. 8(9). pii: E986.

8. Kai Sen Tan#, Yan Yan#, Wai Ling Hiromi Koh#, Liang Li, Hyungwon Choi, Thai Tran, Richard Sugrue, De Yun Wang*, Vincent T Chow*. Comparative transcriptomic and metagenomic analyses of influenza virus-infected nasal epithelial cells from multiple individuals reveal specific nasal-initiated signatures. Front Microbiol, 2018. 9:2685

9. Huong Tra #, Yan Yan#, Muhammad Jumat, Jing Liu, Boon Huan Tan, De Yun Wang, Richard Sugrue*. A sustained antiviral host response in respiratory syncytial virus infected human nasal epithelium does not prevent virus transmission. Virology, 2018. 521, 22-32.

10. Yongkang Qiao#, Yan Yan#, Kai Sen Tan#, Sheryl SL Tan#, Ju Ee Seet, Thiruma Valavan Arumugam, Vincent T Chow, De-Yun Wang*, Thai Tran*. CD151, a novel host factor of nuclear export signaling in influenza virus infection. J Allergy Clin Immunol, 2018. 141(5), 1799-1817.

11. Kai Sen Tan #, Hsiao Hui Ong #, Yan Yan#, Jing Liu #, Yew Kwang Ong, Kim Thye Thong, Hyung Wong Choi, De-Yun Wang*,Vincent T Chow*. In vitro model of fully differentiated human nasal epithelial cells infected with rhinovirus reveals epithelium-initiated immune responses. J Infect Dis, 2018, 217:906-915.

12. Yan Yan#, Kai Sen Tan #, Chunwei Li, Thai Tran, Siew Shuen Chao, Richard J Sugrue, Li Shi, Vincent T Chow *, De-Yun Wang *. Human nasal epithelial cells derived from multiple individuals exhibit differential responses to H3N2 influenza virus infection in vitro. J Allergy Clin Immunol, 2016,138(1):276-281.

获奖及荣誉

2021年:珠海市高层次人才(三类)

2021年:中大五院2020-2021年度优秀科技工作者

2019年:广东省杰出青年医学人才

2017年:中山大学“百人计划二期”青年杰出II类引进人才