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姓名:严志祥

职称: 副研究员
电话: 0756-252-8106
电子邮件: yanzhx3@mail.sysu.edu.cn
通讯地址: 珠海市香洲区梅华东路52号,中山大学附属第五医院

学历和工作经历

1. 教育经历

2012/08-2015/12  澳门大学,生物医药,博士

2009/09-2012/06  南京师范大学,微生物与生化药学,硕士

2005/09-2009/07  南京师范大学,生物技术,学士

2. 科研与学术工作经历

2018/07-至今    中山大学附属第五医院,副研究员

2016/05-2018/05  澳门大学,中华医药研究院,博士后

研究方向

1. 多组学(蛋白组、代谢组、脂质组、微生物组)质谱分析新方法的开发;

2. 多组学大数据分析和生物信息学新方法的开发;

3. 多组学技术研究微生物(肠道菌)与宿主的相互作用;

4. 多组学技术研究心血管疾病、肿瘤等重大疾病的发病机制;

承担科研项目情况

在研科研项目:

1. 国家自然科学基金青年科学基金项目, 31900070,基于代谢组学和宏蛋白质组学解析溃疡性结肠炎肠道菌群代谢变化及机制,2020/01-2022/12,主持,

2. 广东省自然科学基金-面上项目,肠道菌群与宿主甾体代谢基于β-glucuronidase/glucuronide轴的相互关联,2019A1515011771,2019/10.-2022/09,主持

3. 中山大学“百人计划”引进人才科研启动经费,2018/07-2021/07,主持

4. 南方海洋科学与工程广东省实验室(珠海)自主科研项目,SML2020SP003,海洋环境下人体代谢网络调控,2020/11-2023/10,第一参与人

已完成科研项目:

1. 与澳门大学新冠科技攻关合作项目,新型冠状病毒感染的非侵入性代谢组学诊断技术研究,合作申请

代表性成果

近期代表性论文

1. Yan ZX*, He FX, Xiao F, He HH, Li D, Cong L, Lin L, Zhu HJ, Wu YY, Yan R*, Li XF*, Shan H*. A semi-tryptic peptide centric metaproteomic mining approach and its potential utility in capturing signatures of gut microbial proteolysis. Microbiome 2021, 9, 12.

2. Yan ZX*, He FX, He HH, Li D, Pang, PF, Fang ZX, Jiang GM, Huang SW, Li KX, Gu ZQ, Shi HG, Zhang ZY, Zhu HJ , Lin L, Li JL, Yan R*, Xiao F *, Li XF *, Shan H*. Molecular phenomics of gut ecosystem in COVID-19 patients. (https://www.researchsquare.com/article/rs-208797/v1) Microbiome (under review)

3. Lin L#, Jiang X#, Zhang Z, Huang S, Zhang Z, Fang Z, Gu Z, Gao L, Shi H, Mai L, Liu Y, Lin X, Lai R, Yan ZX*, Li X*, Shan H*. Gastrointestinal Symptoms of 95 Cases with SARS-CoV-2 Infection. Gut 2020, 69(6):997-1001.

4. Yan ZX, Yan R*. Exploring the potential of data-independent acquisition proteomics using untargeted all-ion quantitation: application to tumor subtype diagnosis. Analytical Chemistry (2018) 90, 4380-4388.

5. Yan ZX, Yan R*. Improved data-dependent acquisition for untargeted metabolomics using gas-phase fractionation with staggered mass range. Analytical Chemistry (2015) 87, 2861-2868.

6. Yan ZX, Yan R*. Increase the accessibility and scale of targeted metabolomics: construction of a human urinary metabolome-wide multiple reaction monitoring library using directly-coupled reversed-phase and hydrophilic interaction chromatography. Analytica Chimica Acta (2015) 894, 65-75.

7. Yan ZX, Lin G, Ye Y, Wang YT, Yan R*. Triterpenoid saponins profiling by adducts-targeted neutral loss triggered enhanced resolution and product ion scanning using triple quadrupole linear ion trap mass spectrometry. Analytica Chimica Acta (2014) 819, 56-64.

8. Yan ZX#, Gao XJ#, Li T, Wei B, Wang PP, Yang Y, Yan R*. Fecal microbiota transplantation in experimental ulcerative colitis reveals associated host metabolic and gut bacterial reprogramming. Applied and Environmental Microbiology (2018) 84(14), pii: e00434-18.

9. Yan ZX, Yan R*. Tailored sensitivity reduction improves pattern recognition and information recovery with a higher tolerance to varied sample concentration for targeted urinary metabolomics. Journal of Chromatography A (2016) 22, 101-110.

10. Yan ZX, Lin G, Ye Y, Wang YT, Yan R*. A generic multiple reaction monitoring based approach for flavonoids profiling in plants using a hybrid triple quadrupole linear ion trap mass spectrometry. Journal of the American Society for Mass Spectrometry. (2014) 25, 955-965.

获奖及荣誉

1. The 6th Asia Pacific ISSX Meeting, May 11-14, 2018. Hangzhou, China. Best Poster Award First Prize.

2. The 11th Annual International Conference of the Metabolomics Society, June 29-July 2, 2015. San Francisco Burlingame, USA. Travel Award.

3. The 12th Consortium for Globalization of Chinese Medicine (CGCM), August 27-29, 2013. Graz, Austria. Travel Award.

4. The 4th Annual Symposium on Clinical and Pharmaceutical Solutions through Analysis (CPSA). April 24-27, 2013. Shanghai, China. Innovator Award.